Investigating the electrical stimulation of the subthalamic nucleus for the treatment of cortical stroke

Abstract Stroke remains a leading cause of long-term disability in developed countries and the second death worldwide. Recent decades have witnessed substantial progress understanding pathophysiology ischemic stroke treatment stroke-related motor deficit. However, current therapies fail to offer patients satisfactory improvements. Therefore, more effective approach for treating deficit is still needed. Here we investigated effect electrical stimulation subthalamic nucleus (ES-STN) on induced by photothrombotic lesion cortex (MC). We hypothesized that ES-STN can reduce rats. First, The Sprague-Dawley rat (SD rat) was included this pilot study. trained SD with single pellet reaching task (SFPRT) determined baseline performance before surgery. then forelimb region MC. After induction implanted electrode into STN. 4 days after performed while evaluating SFPRT performance. 100 Hz where showed improved during stimulation. At 130 even improvement. histology confirm Our study indicates may be promising cortical A larger scale subjects necessary further investigate stroke. Research Category Technology Methods Basic Research: 1. Deep Brain Stimulation (DBS) Keywords: stroke, nucleus, stimulation, deep brain